Ultraguard For Veterinary Professionals

Hartz® UltraGuard Pro® Flea & Tick Treatment

Active Ingredient – Adulticide

Etofenprox

Etofenprox is the adulticide active ingredient found in Hartz® UltraGuard Pro® Flea & Tick Treatment for Dogs and Cats. The mode of action for etofenprox is similar to traditional pyrethroids. Etofenprox blocks closure of the sodium channels in neurons in the parasite’s nervous system, resulting in excitation. Excitation of the parasite’s nervous system brings about death. Etofenprox is quite different though from traditional pyrethroids in chemical structure and in toxicity profile. The ether unit in the structure of etofenprox, versus the ester unit commonly found in traditional pyrethroids, is what differentiates the active and determines its high margin of safety for warm-blooded animals. With low acute oral and dermal toxicity in mammals, etofenprox provides a safe and effective topical active to control fleas, ticks and mosquitoes on dogs and cats.

The adulticide active ingredient in Hartz® UltraGuard Pro® Flea & Tick Treatment for Dogs and Cats, starts killing fleas within 15 minutes.

Learn How Etofenprox Works

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Insect Growth Regulators: How they work

The Insect Growth Regulators (IGRs) used in Hartz flea and tick products, (S)-Methoprene and Pryiproxyfen, are classified as juvenile hormone mimics. For a parasite to grow, its exoskeleton must be shed because the exoskeleton cannot expand. Various natural hormones within the flea control the shedding of the exoskeleton and physical maturing to older life stages. This process is called “Metamorphosis”. The flea goes through four stages; the egg, larva, pupa and adult.

When flea eggs hatch (or molt), natural hormones allow for the more mature physical traits of a larva to be created. This process repeats again to create the pupa and subsequently the adult stage finally emerges.

Typical
Flea Lifecycle

Eggs hatch in 2–5 days

Larvae go through three stages in 5–10 days before pupating

Pupae develop in 5-10 days and can lie dormant for up to 6 months in a cocoon

Adults emerge and live on one host for up to 2 months

IGRs interfere with a parasite’s metamorphosis. When an IGR is applied to a pet, even with their own hormones being present, IGRs can prevent mature characteristics from emerging and can block the molting process. As a result, the flea dies in the egg or larval stages, never reaching the biting adult stage.

Hartz® Commitment to Safety

Safety Rating of Actives

The formulas in Hartz® UltraGuard® brand products for dogs combine several highly effective, active ingredients and carry an EPA Overall Active Ingredient Safety Profile Designation.

EPA & FDA Regulation

"Hartz wholeheartedly endorses the EPA advisory’s call to action to pet owners regarding the importance of carefully following label directions and making informed decisions when selecting and using spot-on flea and tick pesticides."

—Georgette Wilson, DVM, Hartz Scientific & Medical Affairs

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Adverse Events Facts

A total of 8,764 Adverse Effects were reported to the EPA in 2015 on all registered Flea and Tick Topical treatments for Dogs and Cats.

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Technical Resources

We encourage you to download the following technical reference guides, which provide outstanding insights about flea and tick biology, a summary of EPA safety and approval criteria, summaries and comparative analysis of spot-on flea and tick products, as well as scientific discussion about active ingredients.

Canine Flea And Tick Control, A Reference Guide To EPA-Approved Spot-On Products, Technical Monograph by Jorge Guerrero, DVM, MSc, PhD

Feline Flea And Tick Control, A Reference Guide To EPA-Approved Spot-On Products, Technical Monograph by Michael K. Rust, PhD

Commonly Used EPA Registered Canine Topical Flea and Tick Control Products

Commonly Used EPA Registered Feline Topical Flea and Tick Control Products

Hartz® UltraGuard®

For Dogs

Hartz® UltraGuard®

For Cats

UltraGuard PRO®

3270010875

Hartz® UltraGuard Pro® Flea and Tick Drops for Dogs & Puppies

Starts killing Fleas within 15 minutes.

Monthly treatment kills Fleas, Brown Dog and Deer Ticks, Flea Eggs and Flea Larvae.

Contains dual Insect Growth Regulators (IGR): Pyriproxyfen and (S) Methoprene.

Pro-Glide® applicator to easily penetrate fur for improved application directly to the dog’s skin.

3 Monthly Treatments.

Patented Formula.

Available in 4 weight classes

For use only on dogs and puppies 12 weeks of age and older

Kills Fleas before they have a chance to lay eggs.

Prevents re-infestations for 30 days.

Repels mosquitoes before they bite.

Active Ingredients

Etofenprox
55.0%

Piperonyl Butoxide (PBO)
10.0%

N-octyl bicycloheptene dicarboximide (MGK 264)
1.0%

Pyriproxifen (Nylar)
0.5%

(S) Methoprene
0.25%

UltraGuard Plus®

3270098207_medium

Hartz® UltraGuard Plus® Topical Flea & Tick Prevention for Dogs & Puppies

Starts killing Fleas within 15 minutes

Monthly treatment kills Fleas, Brown Dog Ticks, Deer Ticks and Flea Eggs for 30 days.

Contains Insect Growth Regulator (IGR): Pyriproxyfen

Pro-Cision Flo® applicator to easily penetrate fur for improved application directly to the dog’s skin.

3 Monthly Treatments.

Available in 4 weight classes.

For use only on dogs and puppies 12 weeks and older.

Kills Fleas, Brown Dog and Deer Ticks, and Flea Eggs for 30 days.

Repels mosquitoes before they bite.

Active Ingredients

Etofenprox
55.0%

Piperonyl Butoxide (PBO)
10.0%

N-octyl bicycloheptene dicarboximide (MGK 264)
1.0%

Pyriproxifen (Nylar)
0.5%

UltraGuard®

3270096218_medium

Hartz® UltraGuard® Topical Flea & Tick Prevention for Dogs & Puppies

Starts killing Fleas within 15 minutes

Monthly treatment kills Fleas, Brown Dog Ticks, Deer Ticks for 30 days.

3 Monthly Treatments.

Available in 4 weight classes.

For use only on dogs and puppies 12 weeks and older.

Kills Fleas, Brown Dog and Deer Ticks.

Repels mosquitoes before they bite.

Active Ingredients

Etofenprox
55.0%

Piperonyl Butoxide (PBO)
10.0%

N-octyl bicycloheptene dicarboximide (MGK 264)
1.0%

UltraGuard PRO®

3270010843_medium

Hartz® UltraGuard Pro® Flea and Tick Drops for Cats & Kittens 12 weeks and older

Starts killing fleas within 15 minutes

Monthly treatment kills Fleas, Deer Ticks, Flea Eggs, and Larvae for up to 30 Days.

Repels mosquitoes.

Prevents reinfestations up to 30 days.

Pro-cision Flo® applicator to easily penetrate fur for improved application directly to the cat’s skin.

For cats weighing 5 lbs and over.

Kills Fleas, Deer Ticks, Flea Eggs and Flea Larvae for 30 days.

Prevents re-infestations for 30 days.

Repels mosquitoes before they bite.

Active Ingredients

Etofenprox
40.0%

(S) Methoprene
3.6%

UltraGuard Plus®

3270010844_medium

Hartz® UltraGuard Plus® Flea and Tick Drops for Cats & Kittens 12 weeks and older

Starts killing fleas within 15 minutes

Monthly treatment kills Fleas, Deer Ticks and Flea Eggs for up to 30 days.

Repels mosquitoes.

For cats weighing 5 lbs and over.

Kills Fleas, Deer Ticks and Flea Eggs for 30 days.

Repels mosquitoes before they bite.

Active Ingredients

Etofenprox
40.0%

(S) Methoprene
3.6%

UltraGuard®

3270001915_medium

Hartz® UltraGuard® OneSpot® Flea Egg & Flea Larvae Treatment for Cat and Kittens

Controls and prevents Flea Eggs and Flea Larvae for up to 30 days.

For use only on Cats and kittens 12 weeks and older.

eggs-larvae

Controls and Prevents Flea Eggs and Flea Larvae

Active Ingredients

(S)-Methoprene
2.9%

Hartz® Efficacy

Against Immature Fleas

Efficacy of Hartz® UltraGuard Pro® Triple Action Flea and Tick Drops for Dogs and Puppies in preventing egg hatch and adult emergence of fleas is illustrated below in Table 1.

EPA Guidelines 810.330 – Pre-Adult Flea
A study to measure the efficacy of an Adultcide/IGR product against C. felis egg hatch and adult emergence.

After initial application, weekly collections of C. felis eggs showed reductions of 96% or greater Egg Hatch and 97% or greater Adult Emergence through the 33 day study.

Conclusion:

The study demonstrates that Hartz® UltraGuard Pro® Triple Action Flea and Tick Drops for Dogs and Puppies reduced egg hatch by 96% or greater while reducing adult emergence by 97% or greater through the duration of the 33 day study.

Against Adult Fleas

Efficacy of Hartz® UltraGuard Pro® Triple Action Flea and Tick Drops for Dogs and Puppies against fleas is illustrated below in Table 2.

EPA Guideline 810.3300 – Flea Efficacy
A study to measure the efficacy of an Adultcide/IGR product against a C. felis infestation of dogs.

Forty – eight (48) hours after treatment or weekly reinfestations of 100 C. felis., efficacy readings of 96% or greater were recorded throughout the 30 day study

Conclusion:

The study demonstrates that Hartz® UltraGuard Pro® Triple Action Flea and Tick Drops for Dogs and Puppies maintained an efficacy of 96% or greater against C. felis through the duration of the 30 day study.

Against Ticks

Efficacy of Hartz® UltraGuard Pro® Triple Action Flea and Tick Drops for Dogs and Puppies against ticks is illustrated below in Table 3.

EPA Guideline 810.3300 – Tick Efficacy
A study to measure the efficacy of an Adultcide/IGR product against R. sanguineus infestations on dogs.

Forty – eight (48) hours after weekly reinfestations of 50 R. sanguineus, efficacy readings of 92% or greater were recorded throughout the 30 day study

Conclusion:

The study demonstrates that Hartz® UltraGuard Pro® Triple Action Flea and Tick Drops for Dogs and Puppies maintained an efficacy of 92% or greater against R. sanguineus from Day 9 through the duration of the 30 day study.

Against Immature Fleas

EPA Guideline 810.3300 – Pre-Adult Flea Efficacy
A study to measure the efficacy of an Adulticide/IGR product against an adult C. felis infestation on cats.

The continuous and sustained performance of Hartz® UltraGuard Pro® Flea & Tick Drops for Cats against pre-adult fleas, C. felis, was recorded as greater than 96% through 38 days.

Conclusion:

The test results from this study show that, after weekly reinfestations, Hartz® UltraGuard Pro® is effective in killing adult fleas for 28 days.

Against Adult Fleas

Efficacy of Hartz® UltraGuard Pro® Flea & Tick Drops for Cats has been tested and validated.

EPA Guideline 810.3300 – Flea Efficacy
A study to measure the efficacy of an Adultcide/IGR
product against an adult C. felis infestation on cats

When tested against adult C. felis, UltraGuard Pro for cats exhibited a kill rate of 98% after 2 days. This high performance was maintained through 28 days with 94% mortality of fleas recorded after weekly infestations.

Conclusion:

The test results from this study show that, after weekly reinfestations, Hartz® UltraGuard Pro® is effective in killing adult fleas for 28 days.

Against Ticks

The efficacy of Hartz® UltraGuard Pro® Flea & Tick Drops for Cats against ticks has also been tested and documented (Table 7).

EPA Guideline 810.3300 – Tick Efficacy
A study to measure the efficacy of an Adultcide/IGR product
against Ixodes scapularis infestation on cats.

Mortality data collected on day 32 after application showed 90% kill rate of Ixodes scapularis ticks.

Conclusion:

This study demonstrates that, after weekly reinfestations, Hartz® UltraGuard Pro® provides killing efficacy against Ixodes scapularis ticks for 32 days post treatment.

Concurrent Use and Safety of Multiple Flea and Tick Products

Important Note About the Concurrent Use of Multiple Flea and Tick Products:
Heavy infestations and severe environmental infestations may require multiple flea products. To minimize potential toxic effects, care should be taken to avoid using multiple products with the same mechanism of action (e.g., neonicotinoids, such as imidacloprid and dinotefuran, share similar modes of action).

What Hartz is doing to educate Pet Parents:

Through consumer outreach, Hartz educates pet parents on these basic steps that should be taken for effective and safe product use.

Select the best product(s) for the pet and situation.

· Avoid using multiple products with the same modes of action.
· Always read the labels carefully.
· Follow directions exactly.
· Never use products intended only for dogs on or near cats.
· If in doubt, be sure to seek professional advice.

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